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Notably, His195 features as being a proton donor that can transfer a hydride ion through the nicotinamide ring of NADH to your carbonyl C-atom of the pyruvate, ultimately triggering a reaction to accomplish the oxidation of NADH to NAD+ and the release of NAD+ and lactate (27, 28).Lactate dehydrogenase (LDH) is a crucial enzyme from the anaerobic m